Postdoctoral Researcher

Dr Armel Nicolas

a.nicolas@dundee.ac.uk
Kayo Ono
France
Armel Nicolas

Project Description


I did my PhD in Virology at Ecole Normale Supérieure de Lyon in France where I studied the replication of the small, non-pathogenic helper virus-dependent human Parvovirus "Adeno-Associated Virus" (AAV) under the supervision of Dr. Anna Salvetti. As part of my main project, we collaborated with a proteomics lab in Grenoble to identify by a TAP-tag/LC-MS/MS strategy host and viral proteins which locate into viral replication compartments during Herpes Simplex Virus 1-mediated AAV replication. This first proteomics experiment sparkled my interest for proteomics in general and mass spectrometry in particular. I now work on methods for subcellular fractionation and determination of the localisation of proteins within cells, which I am applying – together with other proteomics workflows – to the study of a wholly different virus: the dreadful Foot and Mouth Disease Virus of the 2001 UK epidemic fame.


Figure
B0003384 Credit David Stuart, Uni. of Oxford, Wellcome Images Structure of foot-and-mouth disease virus The three-dimensional X-ray crystallographic structure of foot-and-mouth disease virus at 2.9 Angstrom resolution. Image created by Ravindra Acharya, Elizabeth Fry, David Stuart, Graham Fox, David Rowlands and Fred Brown. Wellcome Image Award winner 2003 Collection: Wellcome Images Library reference no.: Contributor Reference GOOD COVER.J Copyrighted work available under Creative Commons by-nc-nd 2.0 UK: England & Wales, see http://wellcomeimages.org/indexplus/page/Prices.html


PepTracker
PepTracker provides management and mining capabilities for data generated during mass spectrometry studies.
Data Shop
Visualisation and statistical analysis tool for quantitative datasets
Proteomics Support
The Proteomics Support team have created a website that provides useful resources for proteomics studies.
Encyclopedia of Proteome Dynamics
A collection of multi-dimensional proteome properties from large-scale mass spectrometry experiments
Cell Biologist's Guide
The Cell Biologist's Guide to Proteomics provides information about mass spectrometry and experimentation.