Postdoctoral Researcher

Dr Armel Nicolas
Kayo Ono
Armel Nicolas

Project Description

I did my PhD in Virology at Ecole Normale Supérieure de Lyon in France where I studied the replication of the small, non-pathogenic helper virus-dependent human Parvovirus "Adeno-Associated Virus" (AAV) under the supervision of Dr. Anna Salvetti. As part of my main project, we collaborated with a proteomics lab in Grenoble to identify by a TAP-tag/LC-MS/MS strategy host and viral proteins which locate into viral replication compartments during Herpes Simplex Virus 1-mediated AAV replication. This first proteomics experiment sparkled my interest for proteomics in general and mass spectrometry in particular. I now work on methods for subcellular fractionation and determination of the localisation of proteins within cells, which I am applying – together with other proteomics workflows – to the study of a wholly different virus: the dreadful Foot and Mouth Disease Virus of the 2001 UK epidemic fame.

B0003384 Credit David Stuart, Uni. of Oxford, Wellcome Images Structure of foot-and-mouth disease virus The three-dimensional X-ray crystallographic structure of foot-and-mouth disease virus at 2.9 Angstrom resolution. Image created by Ravindra Acharya, Elizabeth Fry, David Stuart, Graham Fox, David Rowlands and Fred Brown. Wellcome Image Award winner 2003 Collection: Wellcome Images Library reference no.: Contributor Reference GOOD COVER.J Copyrighted work available under Creative Commons by-nc-nd 2.0 UK: England & Wales, see

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