Who we are
Cell protein key to disease susceptibility, in our latest publication- Population-scale proteome variation in human induced pluripotent stem cells.
Professor Angus Lamond FRS, who led the University of Dundee team, said, “We compared the levels of the many thousands of different types of proteins present in stem cell lines generated from different people. “It is very exciting to see how this new data shows variations in protein levels between individuals and how this can help us to understand why some people may be at higher risk of developing disease, or suffering more extreme effects of infection. “The successful outcome of this major study shows the importance of scientific collaborations and long-term support for ambitious research projects.” Human stem cells can divide indefinitely and have the potential to transform into any of the different, specialised types of cells that make up the tissues and organs of the body, such as skin, muscle and nerve cells. A team of researchers, funded jointly by the Wellcome Trust and UK Medical Research Council, created a library of human stem cell lines, using skin cells taken from hundreds of human donors.
Proteins are critical to understanding the mechanisms responsible for disease and inherited disorders and can also affect sensitivity to viral infection and response to drug therapy. This six-year study has revealed new genetic factors that influence susceptibility to certain types of disease, including protein variants linked to increased risk of developing ovarian cancer and Alzheimer’s disease. It is hoped that future work building on this study can help to deliver better targeted therapy and effective new drugs for such conditions.
The Lamond Lab are finally getting back into the laboratory as the University of Dundee gradually opens up after the Covid-19. We hope you and your loved ones all come through this unprecendented time healthy and well. We are excited to get back to great science and lots of entertaining updates on the webpage.
The Immunological Proteomic Resource (ImmPRes) was born in 2015 of a collaboration between the Laboratory for Quantitative Proteomics and the Division of Cell Signalling & Immunology within the School of Life Sciences at the University of Dundee. ImmPRes was created with the aim to provide an in-depth, high quality, quantitative map of the immuno proteome. One focus is T cells and here the data includes analysis of how antigen, cytokines and key intracellular signalling pathways and environmental stimuli restructure T cell proteomes. ImmPRes is an open access public resource integrating proteomic data generated by large-scale quantitative mass-spectrometry for murine immune cell populations. The resource contains data for both the adaptive and innate immune system.