Who we are
Research in the Lamond Lab that has created powerful new software tools for management, visualisation and analysis of proteomics big data has led to the formation of a new Univeristy of Dundee Spin out company called Platinum InformaticsPlatinum informatics has been awarded a SMART:SCOTLAND feasibility grant from Scottish Enterprise. The award will allow the development of a 'Processing Pipeline', a cloud-based 'Big Data' processing and analysis tool. This will further expand their suite of software for advanced data management. Platinum have also made the Converge Challenge Top 30. Converge Challenge is the leading, pan Scotland, company creation programme for staff, students and recent graduates of Scottish Universities and Research Institutes with the aim of creating a new generation of entrepreneurs in Scotland. We wish them every success in this entrepreneurial endeavour.
Members of the Lamond Lab (Tony Ly, Aki Endo, Alejandro Brenes, Vackar Afzal, Andrea Pawellek and Angus Lamond) have generated one of the most comprehensive analyses of the changes in the regulation and turnover of proteins in response to Src activation of cancer transformation published in Wellcome Open Research Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells. The signature of Src-responsive proteins is highly predictive of poor patient survival across multiple cancer types.
‘Volcano’ plots of –log10 p-value versus log2 fold change for the seven time points of Src activation, and cancer transformation.
Not only are these data available through the Wellcome Open Research portal but also through The Encyclopedia of Proteome Dynamics where you can investigate the effects of Src transformation on your proteins of interest.
A collaboration with Professor Fiona Watt at Kings College London (Centre for Stem Cells & Regenerative Medicine), Tony Ly, Haru Yoshikawa, and Angus Lamond has shown the effect of stalled ribosomes on the homeostasis of the epidermis, An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis published in Nature.
"Different mRNA features can lead to ribosome stalling during translation elongation. Because the accumulation of stalled ribosomes on mRNAs is toxic, cells have evolved mechanisms to rescue and recycle stalled ribosomes by inducing their release and the degradation of the associated nascent polypeptides." A protein responsible for this rescue mechanism, Pelota (Pelo), when knocked out, resulted in loss of effective skin barrier function, scaly skin and epidermal thickening.